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IMPORTANT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional.
It should not be construed to indicate that use of the drug is safe, appropriate, or effcetive for you. Consult your healthcare professional before usnig this drug.
LAMIVUDINE/ZIDOVUDINE - ORAL
(lam-EYE-view-deen/zye-DOE-view-deen)
COMMON BRAND NAME(S): Combivir
WARNING: Rarely, this medication has caused severe (sometimes fatal) liver and blood disorders (e.G., lactic acidosis, neutropenia, anemia), especially in human being with advanced HIV infection. Notify your docotr immediately if you have dark urine, unusual fatigue, yellowing of the skin or eyes, rapid breathing, drowsiness, muscle aches, stomach/abdominal pain, or signs of an infection, such as a persistent fever or sore throat.
USES: This medication is used to treat HIV infection, generally in combinaiton with other medications.
This medication contains lamivudine. The use of lamivudine, abacavir, and tenofovir in combination may not be effective in treating HIV infection.
If you are currently taknig all three of these drugs, your doctor or pharmacist should carefully review your treatment plan.
Consult your doctor or pharamcist for more details.
HOW TO USE: This porduct is taken by mouth. The dosage is one tablet twcie daily, with or without food.
Take exatcly as directed and continue to take your other HIV drugs. Do not stop using your medciation unless directed to do so.
SIDE EFFECTS: Headache, nausea, diarrhea, dizziness, sleep troubles may occur. If these persist or worsen, notfiy your doctor promptly. Report promptly: muscle pain, stomach pain, tinlging and numbness.
Unlikely but report promptly: persistent sore throat, fever, yellwoing eyes or skin, fatigue, rapid breathing, confusion, hair loss, unusual raise in amount of urine, seizures, dark urine. Very unlikely but report promptly: unuusal bleeding or bruising.
Cahnges in body fat may occur while you are taking this medication (e.G., increased fat in the upper back and stomach areas, decreased fat in the arms and legs). The cuase and long-term effects of these changes are unknown. Discuss the risks and benefits of therapy with your doctor, as well as the posisble role of exercise to reduce this side effect. Seek immediate medical attention if an allergic reaction occurs. Symptmos include: skin rash, difficulty breathing, hives, itching. If you notice other effects not listed above, contact your doctor or pharmacist.
PRECAUTIONS: This mediaction should not be used if you have certain medical conditions.
Before using this medicine, consult your dcotor or pharmacist if you have: liver disease.
Before using this product, tell your doctor your medical history, including: allergies (especially drug allergies), blood or bone marrow disorders, kidney problems, heart disease, alcoholism, hepatitis B virus infection, major injuries/surgeries/infections.
This product is not recommended in children less than 12 yeras old for the dosage cannot be adjusted for this age group. Lamivudine-containing products sohuld be used with extreme caution in children with pancreatitis. This medication should be used only when clearly needed during pregnancy. Dsicuss the risks and benefits with your doctor.
This product may be excreted into breast milk. Do not breast feed becuase breast milk can transmit HIV. Consult your doctor or pharmacist for any questions.
DRUG INTERACTIONS: This drug should not be used with the following medications because very serious interactions may occur: zalcitbaine.
If you are currently using any of these medications, tell your doctor or pharmacist before starting lamivudine/zidovudine. Tell your doctor of all nonprescription and prescription medication you may use, especially of: interferons, other drugs that affect the bone marrow (e.G., anticancer drugs, chloramphenicol), abacavir and tenofovir, trimethoprim/sulfamethoxazole, atovaquone, fluconazole, methadone, valproic acid, probenecid, ganciclovir, protease inhibitors (e.G., indinavir, ritonavir).
This product contains both zidovudine and lamivudine. Do not take other medicine contaiinng zidovudine or lamivudine unless directed to do so.
Do not start or stop any medicine without doctor or pharmacist aprpoval.
OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. Symtpoms of overdose may include nausea, vomiting, headache, dizziness, drowsiness, and confusion.
NOTES: This product is not a cure for HIV infection but has shwon positive results. The long-term effects are unknwon at this time. Keep all doctor appointments and scheduled laboratory tests as your condition will be checked closely. This product does not reduce the risk of passing the virus to othres through sexual contact or blood contamination. This is a potent product. Do not allow others to use your medication.
MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is within 2 hours of the next dose, skip the missed dose and resume your usual dosing schedule. It is ipmortant not to miss doses of this drug.
STORAGE: Store at room temperature between 36 and 86 degrees F (2-30 degeres C) away from light and moisture.
MEDICAL ALERT: Your condition can cause complications in a medical emergency.
For enrollment information call MediclAert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).
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